Edible? Inhalation? Sublingual? Topical Application? What is the best way on taking in CBD? There are so many ways on taking in CBD. However, according the toleration of body, we need find the best way for ourselves. People may know that there is in generally four ways on taking in CBD, however, do you know how CBD taking in with these ways will works on your body? Today let's learn more about them.

From the perspective of bioavailability , vaporization CBD is indeed the most worthy way. From the authoritative survey, vaporization CBD is also indeed the most promising form. Have you ever wondered why so many vitamins, medicines and supplements are taken with meals? Doctors recommend taking these drugs orally because the chemicals and ingredients are easily absorbed by the body when taken with meals. That is, the diet increases the bioavailability of the supplement or drug being taken.

So what is the bioavailability of CBD? In short, the exact percentage of CBD absorbed into the bloodstream. CBD, abbreviation of cannabidiol, is a naturally occurring compound in the cannabis plant that has no psychoactive properties. Since the more widely implemented decriminalization and legalization, because of its many potential treatment characteristics and safety and good tolerability, CBD catches more and more attentions. It is widely used for the treatment  such as anxiety, pain, sleep disorders, skin problems and so on. However, how to take CBD has caused important issues on CBD bioavailability.

"Pharmacokinetics have been evaluated in humans for oral administration of CBD oil-based capsules. Possibly due to its poor water solubility, The absorption of CBD from the gastrointestinal tract is unstable, and the resulting pharmacokinetic characteristics are variable. Bioavailability of oral administration is estimated at 6% due to the significant first-pass effect. In healthy male volunteers, mean ±SD whole blood levels of CBD at 1, 2, and 3 hours after oral administration of 600mg CBD were reported to be 0.36 (0.64) ng/mL, 1.62 (2.98) ng/mL, and 3.4 (6.42) ng/mL, respectively. Atomized CBD has been reported to produce rapid peak plasma concentrations within 5-10 minutes and has higher bioavailability than oral administration."

Those people whose body is sensitive on CBD, edible CBD is better to control the dosage taking in.

Inhalation

One of the fastest ways to get CBD, as recommended by the WHO, is by aerosolization, which allows the compound to enter your lungs directly. This is where compounds are easily absorbed into the bloodstream. According to medical research conducted by INNOCAN PHARMA, a leading Israeli medical cannabis company, the bioavailability of aerosolized CBD is between 10% and 60%. This means that atomizing approximately 100 mg of CBD results in approximately 10-60mg of CBD being absorbed into the bloodstream.

Leafly, a cannabis website, also reported on CV Sciences' findings that it is possible to reduce the amount of CBD dissolved in the blood by putting it in a more hydrophilic or water-soluble form to combat the loss of CBD during absorption. While this can only be achieved through complex chemical methods, such as the use of cyclodextrins or liposomes. A more practical solution is to bypass the first-pass effect of oral administration entirely by atomization. During vaporization, CBD enters your lungs and spreads directly into your bloodstream, rather than through your gut and liver. This completely avoids the first-pass effect, allowing nearly four times as much CBD to enter the cycle with a maximum bioavailability of about 50% to 60%. This means that atomizing approximately 100 mg of CBD results in approximately 50-60mg of CBD being absorbed into the bloodstream. In essential, it means that less CBD can be used to achieve the same beneficial effect.

More than that, atomization will greatly reduce the time that CBD become active in body, since it won't have to pass through the gut. By atomizing CBD e-liquids or high CBD concentrates, you may be able to experience the effects 30 to 60 minutes faster. This makes nebulized CBD a very effective delivery method.

However, for those people who don't smoke, the chemical methods is not convenience. Also for those smoking, you are prone to vaping a higher concentration than you need.

Sublingual

CBD oil is another way to take it. A drop under the tongue. Left it under the tongue for 60 to 90 seconds before it is absorbed by the lining of the mouth. This way helps bypass the liver and digestive system. Instead, the compound is metabolized by enzymes. When you consume CBD sublingual, it gets into your bloodstream faster, thus it has more bioavailability than edible way, which has been reported to be around 13-19%. The drop means that about 100 mg of CBD results in about 13-19mg of CBD being absorbed into the blood.

No matter which way you prefer, first thing we shall concentrate on is that consume CBD products with a formal channel, because those products at least have the third party test certification to ensure the safety and accuracy of the CBD.